En NCI-studie som slagit mycket väl ut!
"A significant upregulation in MDR1 was observed in the BEL/AZC arm"
http://abstractsearch.asco.org/cgi-bin/ts.pl?index=442064&query=belinostat&opt=any
Conclusions: The combination of BEL and AZC is feasible, responses have been observed in several pts at the RP2D of 1000mg/m2 of BEL plus 75mg/m2 AZC. A significant upregulation in MDR1 was observed in the BEL/AZC arm at day 5 compared with the AZC alone arm, suggesting a relative biologic contribution of BEL to the combination. The clinical correlates of these observations require evaluation in the context of a larger trial.
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"A significant upregulation in MDR1 was observed in the BEL/AZC arm"
http://abstractsearch.asco.org/cgi-bin/ts.pl?index=442064&query=belinostat&opt=any
Conclusions: The combination of BEL and AZC is feasible, responses have been observed in several pts at the RP2D of 1000mg/m2 of BEL plus 75mg/m2 AZC. A significant upregulation in MDR1 was observed in the BEL/AZC arm at day 5 compared with the AZC alone arm, suggesting a relative biologic contribution of BEL to the combination. The clinical correlates of these observations require evaluation in the context of a larger trial.
Sendt fra ProInvestor gruppen
19/5 2011 10:39 Gorm 0
42623 MDR 1 är ett protein som spelar stor roll vid utvecklingen av multiresistens mot läkemedel. Lyckas man hålla MDR 1 utanför cellerna, dvs man mäter en högre nivå extracellulärt som i detta fall? så är det utmärkt. Uppregulation kan kanske även tolkas som att man via behandlingen ändrar själva proteinstrukturen/funktionen av MDR 1.
