Announcement
04.04.2011

NeuroSearch A/S (NEUR) announces that the first ex-HART patient has been
successfully enrolled in Open HART, which is an open-label safety extension to
the HART study.

The HART study was a 12-week North American Phase IIb study evaluating
Huntexil® for the treatment of Huntington's disease. In HART, 227 patients were
enrolled and randomized to double blind treatment with 10, 22.5 or 45 mg
Huntexil® or placebo twice daily.

The Open HART study evaluates the long-term safety of Huntexil® and was planned
and initiated at the request of ex-HART patients who expressed an interest in
continued treatment with Huntexil® on an open-label basis.

Patrik Dahlen
CEO


Contact persons
Patrik Dahlen, CEO, telephone: +45 4460 8214 or +45 2629 7296
René Schneider, EVP & CFO, telephone: +45 4460 8700 or +45 2911 2097

About Huntexil® (pridopidine)
Pridopidine acts as a dopaminergic stabiliser and is the first compound in a
new class of pharmaceutical agents, dopidines to have demonstrated clinical
effect. Dopidines have the unique ability to stabilise the dopaminergic system,
i.e. to either enhance or inhibit dopamine dependent functions in the brain,
depending on the initial level of dopaminergic activity.

Pridopidine inhibits dopamine activation of the D2 receptor with a preference
towards the high affinity (activated) receptor state and has no detectable
agonist activity on this receptor. In vivo, pridopidine strengthens glutamate
function in the frontal cortex, which may add to the agent's powerful
behavioural effects in states of excessively high dopamine activity or
excessively low glutamate activity, while not affecting behaviour under normal
conditions. Together, these findings suggest that pridopidine stabilises
psychomotor activity in states of hypo- and hyperactivity by means of
functional D2 antagonism and strengthening of cortical glutamate functions.

About Huntington's disease
Huntington's disease is a highly disabling, incurable and fatal genetic
disorder, which leads to damage of the nerve cells in certain areas of the
brain including the basal ganglia and the cerebral cortex. The disease is
hereditary and every child of someone with Huntington's disease has a 50%
chance of inheriting the disease.

Patients with Huntington's disease experience a wide variety of symptoms, which
typically can be grouped into three categories: motor dysfunction includes loss
of muscle co-ordination, parkinsonism, chorea, dystonia, and abnormal gait and
posture, which can markedly impair patients' daily functioning. Impaired
executive and cognitive functions lead to loss of organizational and planning
skills, and psychiatric changes, such as depression and anxiety, are typical;
manic and psychotic symptoms can also be present. The onset of symptoms is
typically around 35-45 years of age, after which patients deteriorate gradually
and have a life expectancy of 10-20 years.

Patients with Huntington's disease will eventually require full-time care, and
the therapy area has high unmet medical needs. No cure or effective treatment
is available and only a limited number of novel drugs are in development. The
prevalence of Huntington's disease is about 1: 10 000 in most western
countries, corresponding to an estimated 70 000 affected patients in North
America and Europe combined. In other parts of the world, the prevalence varies
substantially and is generally lower.

About NeuroSearch - Company profile
NeuroSearch A/S is a European based biopharmaceutical company, specialising in
CNS diseases, and listed on NASDAQ OMX Copenhagen A/S (NEUR). The company has a
pipeline of speciality CNS drugs, including Huntexil® (pridopidine), a unique
orphan drug in Phase III for the treatment of Huntington's disease. NeuroSearch
is building commercial competences with a view to commercialising Huntexil®
through an in-house marketing and sales organisation.

NeuroSearch has a well-established drug discovery division, NsDiscovery, with
unique capabilities in the field of ion channels and CNS diseases. The company
has strategic drug discovery and development alliances with Janssen
Pharmaceutica and Eli Lilly as well as a licence collaboration with Abbott.
NeuroSearch also has equity interests in a number of unlisted companies in the
Life Science industry.