Cantargia reports positive results for CAN10 antibody
99409 Helge Larsen/PI-redaktør 13/12 2021 14:08
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11.00 PM CET / 13-Dec-2021 / Cantargia AB (STO:CANTA)
Cantargia reports positive results for CAN10 antibody in preclinical systemic sclerosis model
Cantargia AB today reported new preclinical results demonstrating efficacy of the CAN10 antibody in a systemic sclerosis disease model where CAN10 counteracted disease development in the skin and lungs. Notably, the levels of several biomarkers affected in systemic sclerosis patients were normalized by CAN10 in this model. These results support clinical development of CAN10 in systemic sclerosis and results are planned to be presented at a scientific conference during Q1 2022.
The CAN10 antibody binds interleukin-1 receptor accessory protein (IL1RAP) with high affinity and functions through simultaneous blockade of IL-1, IL-33 and IL-36 signaling. Development of CAN10 is initially planned to focus on two severe diseases: myocarditis and systemic sclerosis.
Systemic sclerosis is a life-threatening autoimmune disease involving inflammation and subsequent fibrosis, i.e. uncontrolled scar tissue formation, in skin and internal organs. In an in vivo systemic sclerosis model, a surrogate CAN10 antibody reduced disease development in both skin and lungs. Further analyses of the skin also revealed that CAN10 normalized several biomarkers, i.e. gene signatures, which were dysregulated in skin biopsies from systemic sclerosis patients, suggesting that IL1RAP inhibition by CAN10 may lead to the same benefits in human disease as well. Together, these results support the clinical development of CAN10 as a new first-in-class treatment of systemic sclerosis and results are planned to be presented at a scientific conference during Q1 2022.
"We are excited about these new results, showing strong effects of CAN10 in a systemic sclerosis model. Cantargia is committed to develop new therapies for life-threatening diseases and we look forward to advance this promising project to treatment of patients." said Göran Forsberg, CEO of Cantargia.
The CAN10 antibody is in late-stage preclinical development. Cantargia plans to initiate a clinical phase I study for CAN10 in Q3 2022.
For further information, please contact:
Göran Forsberg, CEO
Telephone: +46 (0)46-275 62 60
E-mail: [email protected]
Cantargia har betalt IR-aftale med ProInvestor.com
Cantargia reports positive results for CAN10 antibody in preclinical systemic sclerosis model
Cantargia AB today reported new preclinical results demonstrating efficacy of the CAN10 antibody in a systemic sclerosis disease model where CAN10 counteracted disease development in the skin and lungs. Notably, the levels of several biomarkers affected in systemic sclerosis patients were normalized by CAN10 in this model. These results support clinical development of CAN10 in systemic sclerosis and results are planned to be presented at a scientific conference during Q1 2022.
The CAN10 antibody binds interleukin-1 receptor accessory protein (IL1RAP) with high affinity and functions through simultaneous blockade of IL-1, IL-33 and IL-36 signaling. Development of CAN10 is initially planned to focus on two severe diseases: myocarditis and systemic sclerosis.
Systemic sclerosis is a life-threatening autoimmune disease involving inflammation and subsequent fibrosis, i.e. uncontrolled scar tissue formation, in skin and internal organs. In an in vivo systemic sclerosis model, a surrogate CAN10 antibody reduced disease development in both skin and lungs. Further analyses of the skin also revealed that CAN10 normalized several biomarkers, i.e. gene signatures, which were dysregulated in skin biopsies from systemic sclerosis patients, suggesting that IL1RAP inhibition by CAN10 may lead to the same benefits in human disease as well. Together, these results support the clinical development of CAN10 as a new first-in-class treatment of systemic sclerosis and results are planned to be presented at a scientific conference during Q1 2022.
"We are excited about these new results, showing strong effects of CAN10 in a systemic sclerosis model. Cantargia is committed to develop new therapies for life-threatening diseases and we look forward to advance this promising project to treatment of patients." said Göran Forsberg, CEO of Cantargia.
The CAN10 antibody is in late-stage preclinical development. Cantargia plans to initiate a clinical phase I study for CAN10 in Q3 2022.
For further information, please contact:
Göran Forsberg, CEO
Telephone: +46 (0)46-275 62 60
E-mail: [email protected]
Cantargia har betalt IR-aftale med ProInvestor.com
