Genmab

	29/4 08:21 af Hamming	Enapotamab er " next up"
	29/4 08:21 af Hamming	(link)
	29/4 06:37 af bibob	God morgen. :-)
	29/4 06:29 af transalp	Go morgen.. :)
	28/4 21:59 af GeorgeBest	Sounds like Novartis will be very aggressive in maketing ofa in MS...
	28/4 21:21 af E L	quite a few comments/ questions on ofatumumab
	28/4 21:20 af E L	Novartis AG (NVS) CEO on Q1 2020 Results - Earnings Call Transcript (link)
	28/4 21:17 af Helge Larsen/PI-redaktør	(link)
	28/4 14:17 af Solsen	No doubt that CD37 could be huge. I have seen many articles about the synergy with CD20 but also CD37 alone. (link) (link) and yes perhaps included in the bag in the coming partnerdeal.
	28/4 14:08 af gentogen	En detalje fra artikel: We speculate that combinations of DuoHexaBody-CD37 with pro-apoptotic PI3K-δ-inhibitors such as idelalisib may work synergistically,
	28/4 13:34 af E L	Usmani starts a small trial of Dara-Pembro for Heavily pre-treated Multiple Myeloma Patients (link)
	28/4 13:07 af E L	it is a University Medical Centre, in Leiden. Parren is a Professor there, maybe she is doing her Phd with him there
	28/4 12:46 af gentogen	By the way, it looks like the first author Simone Oostindie is not only at Genmab but also works at the same place as Paul Parren
	28/4 12:43 af gentogen	In the article (looks absolutely great) they also have a reference to this one; "CD20 And CD37 Antibodies Synergize To Activate Complement By Fc-Mediated Clustering". It also looks very promising: (link)
	28/4 12:24 af troldmanden	Helst ikke JnJ. Ikke for mange store æg i samme kurv....
	28/4 12:20 af E L	i think we could all be happy with those
	28/4 11:41 af Sukkeralf	My preferred partner would be Novartis or Janssen at the moment
	28/4 11:25 af E L	interesting thoughts... -from both
	28/4 11:22 af Sukkeralf	But maybe Genmab want to see some data before they decide if it should part nered up
	28/4 11:19 af Sukkeralf	E L could it be combined with CD20/CD3 or just CD20 antibodies - again maybe important for a epcoritamab deal if DuoHexa-CD37 should be included
	28/4 11:01 af bongobob	Yes, very impressive article. Truly a leap frog candidate. No competition. I was wondering if we could see this in MS like Ofa
	28/4 11:00 af E L	the enthusiasm here is overwhelming ;-)
	28/4 10:45 af E L	Combinations of DuoHexaBody-CD37 with anti-CD20 antibodies could be of particular interest
	28/4 10:44 af E L	induced significant inhibition of tumor growth

	28/4 10:43 af E L	[it was also] shown to efficiently engage with FcγRs in mediating ADCC and ADCP, indicating the mechanism of action of DuoHexaBody-CD37 is multifaceted.
	28/4 10:42 af E L	the threshold for complement activation by DuoHexaBody-CD37 might be lower, which could result in enhanced anti-tumor efficacy in clinical settings. This could be of specific interest for patients who no longer respond to CD20 mAb treatment regimens,
	28/4 10:41 af E L	DuoHexaBody-CD37 not only outperformed all other CD37 antibody variants evaluated in ex vivo CDC assays using primary CLL patient samples, but also outperformed approved CD20 mAbs rituximab, ofatumumab and obinutuzumab.
	28/4 09:04 af E L	follows the new trial @gentogen posted yesterday
	28/4 09:04 af E L	Blood Cancer Journal: DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies (link)
	28/4 09:00 af E L	Jeffrey Cohen, MD: The Success of Ofatumumab in Relapsing MS (link)
	28/4 08:21 af bibob	God morgen. :-).
	28/4 07:41 af transalp	Go morgen.. :)
	28/4 07:16 af JKY_VH	haha peter12 og god morgen:-) Håber at vi snart kan sige det samme om Novod.
	27/4 23:19 af peter12	Genmab har en ny fan (link)
	27/4 17:06 af E L	yes, noted the same, seems like a bit of rotation, pharma has admittedly done very well
	27/4 17:03 af Helge Larsen/PI-redaktør	Der var flere pharma aktier som faldt tilbage i eftermiddag.
	27/4 17:00 af Bulder	det var da den ringeste lukkeauktion nogensinde
	27/4 12:42 af peter12	Vi afventer rapporten ...
	27/4 12:17 af peter12	Lidt læsestof til pensionisten. Ved ikke om det har været linket før ? ;-) (link)
	27/4 09:33 af E L	thanks. will give Jan something to talk about next week ;-)
	27/4 09:27 af gentogen	(link)
	27/4 09:27 af E L	no, not yet, we were waiting for that one, IND was filed, You have the link pls?
	27/4 09:26 af gentogen	= (DuoHexabody®-CD37)
	27/4 09:24 af gentogen	Har denne været omtalt? First-in-Human (FIH) Trial of GEN3009 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphomas
	27/4 09:24 af Sukkeralf	They try once more
	27/4 09:22 af gentogen	ADC THERAPEUTICS FILES REGISTRATION STATEMENT FOR PROPOSED INITIAL PUBLIC OFFERING (link)
	27/4 08:08 af E L	Halozyme Announces Janssen Submits New Drug Application In Japan For Daratumumab Subcutaneous Formulation Utilizing Halozyme's ENHANZE® Technology For Patients With Multiple Myeloma (link)
	27/4 07:50 af transalp	Den venter jeg stadig på heroppe nord på, regen altså.. :) og en go gen uge,
	27/4 07:42 af bibob	Og endelig kom regnen. :-) ;-)
	27/4 07:41 af bibob	God morgen :-)