Genmab

	16/6 15:55 af GeorgeBest	Hvis sc glofi bliver godkendt, så skal patienten først forbehandles med et andet stof obinutizunab (iflg Bulders link 22:10). Lyder mindre convenient end epco. Men er ikke ekspert så kun et gæt fra min side
	16/6 15:42 af Solsen	Tvivler på at der bliver et h2h forsøg mellem de to stoffer. Men i min optik - måske baised - står epco meget stærkt med nu mulighed for sc version og outpatient behandling. Lige nu er glofitamab med iv på sygehus i rigtig mange timer.
	16/6 15:29 af lahn1	Thx , har vi et sammen ligningsgrundlag vs glofi combi (gemOX) ?
	16/6 14:50 af GeorgeBest	Yes, but the comparison epco vs glofi would have been more relevant and interesting. glofi is the most potent of the Roche cd3/cd20
	16/6 13:47 af lahn1	Epco gonna make gmab look like a f^#ing legend!. Worse pre treated pts popl. More covid and comes out better .
	16/6 11:22 af E L	Epcoritamab versus mosunetuzumab in patients with R/R FL: findings of a MAIC (link)
	16/6 08:10 af ProInvestorNEWS	Roche : Phase III Study Of Columvi Combo Extends Survival In Relapsed Diffuse Large B-Cell Lymphoma (link)
	15/6 21:34 af Solsen	Umiddelbart ser Genmab/Abbvie ud til at stå med en fordel her de næste år.
	15/6 21:32 af Solsen	Gad vide om de med det fase 1b samt involvering af et yderligere stof kan konvertere alle evt godkendelser i Glofitamab til sc-versionen ?
	15/6 21:18 af GeorgeBest	Tusind tak
	15/6 21:14 af Bulder	Studiet ser ud til at være færdigt om et år.
	15/6 21:10 af Bulder	(link)
	15/6 21:05 af Solsen	Iam not updated. But looking at Halozymes presentation at Roches last Q report Glofitamb/Columvi are not mentioned in a sc versions.
	15/6 20:03 af GeorgeBest	How far away is Roche to get a subcutaneous formulation for glofitamab? Or have they given up on that?
	15/6 19:09 af Solsen	Very good with the sc outpatient regime. Competitive advantage.
	15/6 18:16 af E L	(link)
	15/6 18:16 af E L	Lymphoma Hub @lymphomahub CONGRESS #EHA2024 \| Umberto Vitolo reports 1st results from EPCORE NHL-1 FL cycle 1 optimization (C1 OPT) cohort investigating mitigation strategies for CRS with no mandatory hospitalization in pts with R/R FL receiving epcoritamab. (link)
	15/6 18:13 af E L	The Lancet - Epcoritamab monotherapy in patients with relapsed or refractory follicular lymphoma (EPCORE NHL-1): a phase 2 cohort of a single-arm, multicentre study (link)
	15/6 13:24 af E L	Felipe Peña Muñoz @HematoRules #EHA2024 BiTEs and #CART in #Lymphoma- (link)
	15/6 13:03 af E L	Lymphoma Hub @lymphomahub CONGRESS \| #EHA2024 \| David Lavie, Hadassah Medical Center presents first data of SC administration of epcoritamab + POLA-R-CHP for the treatment of first-line DLBCL. ORR 100%, CR 88.6%, median duration of CR not reached, Grade 3/4 TEAE 76%, neutropenia 65% (all GR 3/4), CRS 49%, CRS resolution 100% (link)
	15/6 13:03 af E L	would certainly hope so
	15/6 12:47 af Bulder	Ja, når dara kan, kan superdara vel også?
	15/6 12:16 af gentogen	(link)
	15/6 12:11 af E L	another 180 patients into the EPCORE™FL-2 trial (link)

	15/6 11:59 af E L	The Lancet Oncology @TheLancetOncol · 26 m Presenting now at #EHA2024 ⬇️ Long-term follow-up of CASSIOPEIA: Bortezomib, thalidomide & dexamethasone with or w/o daratumumab and followed by daratumumab maintenance or observation in transplant-eligible newly diagnosed multiple (link) (link) (link)
	15/6 11:57 af E L	incidentaly they have not yet removed BNT313/GEN10533 from their pipeline, but i guess they will soon do that. We did get fair warning at the last call around Profound bio from Genmab that they would be even more rigoureus looking at the assets in their pipeline given the additional assets they are taking on
	15/6 11:54 af E L	BioNTech at ASCO 2024 presentation / acasunlimab (link)
	15/6 11:38 af E L	besides Lupus also abstract on DARATUMUMAB FOR REFRACTORY SYSTEMIC RHEUMATIC DISEASES: A SINGLE CENTER EXPERIENCE -very large pdf (link)
	15/6 11:28 af E L	Md Yuzaiful Md Yusof @Yuz6Yusof #EULAR2024 LBA0007 More evidence on deep Bcell depletion in #lupus. Open label trial of Daratumumab, anti-CD38 plasma cell Ab showed rapid reduction in biomarker endpoint, dsDNA, as well as SRI-4 & CLASI-A at Wk12. No SAE but longer F/U needed since IgG reduced by 6g/L (link) abstract (link)
	15/6 06:14 af bibob	God morgen. :-)
	15/6 06:10 af Helge Larsen/PI-redaktør	Godmorgen :-)
	14/6 20:26 af Solsen	Thanks EL. Epco looks very promising.
	14/6 20:21 af E L	:-D i am sooo sorry , i really don't want to push the price down, but i can not find enough bad news to keep it up ;-)
	14/6 19:14 af lahn1	EL, are you censoring the news. You only seem to report good news ?
	14/6 18:11 af E L	TALVEY® (talquetamab-tgvs) demonstrates highly durable, longer-term responses in patients with relapsed or refractory multiple myeloma (link)
	14/6 15:57 af E L	are we expecting new data at EHA, or have we seen all at ASCO? haven't compared the abstracts...
	14/6 15:56 af E L	#EHA2024 Epcoritamab (link) (link)
	14/6 15:46 af bikube	$ kursen er fint oppe, men det VIXen også +10%
	14/6 15:34 af gdn55	Det er godt nok ærgerligt, at vi ikke mere kan se hvem der køber og sælger.
	14/6 15:29 af E L	We haven't lost focus, BioNTech insists (link) / acasunlimab
	14/6 14:40 af Darvin	Nu har vi haft en l…. Kurs i lang tid . Hvad betyder en kort tid mere ? Der er så meget fundamentalt gods i Genmab, at efter det har været ned ad bakke, så skal vi snart op ad bakke - nyd turen når den kommer, om det så varer lidt. Det kan ikke ryste mig og God weekend herfra :-D
	14/6 11:18 af Riis7	Der er ellers god dollar medvind igen, men det hjælper ikke rigtigt mere
	14/6 11:10 af w	11.18, der er jo ingen shorts af betydning
	14/6 10:27 af concillado	Juni måned har historisk altid været en hård nyser for GEN. Ren agurketid ;-)
	14/6 10:18 af lahn1	Der arbejdes hårdt på at få kursen ned. Flotte savhakker med lavere bunde hver gang.
	14/6 10:06 af Raun	@gentogen kl. 22.10 - Det vil godt nok være en svinestreg. - Med mindre at budet kommer samtidigt....
	13/6 21:10 af gentogen	Hvis de vil give et bud, så opter de vel først ud...
	13/6 20:55 af Sukkeralf	Bare det ikke ender med “The best did never come”
	13/6 20:54 af Sukkeralf	Hhhmm og 1056 er vel også død. Synes det kniber for HexaBody teknologien :-(
	13/6 20:48 af Solsen	Gen1053 terminated due to strategic evaluation (link)